Autor:	Charlotte L. Barney, Edward W. Huber, James R. McCarthy
Rok vydání:	2010
Předmět:	Direct route Primary (chemistry) Chemistry Organic chemistry General Medicine Reductive amination Amination
Zdroj:	ChemInform. 22
ISSN:	0931-7597
DOI:	10.1002/chin.199140116
Popis:	Ketones and α-trifluoromethylketones were converted to primary, secondary, and tertiary amines in good to excellent yields by a reductive amination procedure utilizing TiCl 4 /NaCNBH 3 . The method provides the first direct route to α-trifluoromethylamines from ketones, and access to hindered amines from ketones which are unobtainable by Borch reducttve amination.
Databáze:	OpenAIRE
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