Enantiomer Separation by Capillary SFC and GC on Chirasil-Nickel: Observation of Unusual Peak Broadening Phenomena

Autor:	Michael Schleimer, Markus Fluck, Volker Schurig
Rok vydání:	1994
Předmět:	chemistry.chemical_compound Nickel chemistry Capillary action Phase (matter) Carbon dioxide Analytical chemistry Supercritical fluid chromatography chemistry.chemical_element Gas chromatography Enantiomer Supercritical fluid Analytical Chemistry
Zdroj:	Analytical Chemistry. 66:2893-2897
ISSN:	1520-6882 0003-2700
DOI:	10.1021/ac00090a016
Popis:	Immobilized chirasil-nickel (nickel(II) bis[3-(heptafluorobutanoyl)-(1R)-10-methylenecamphorate] chemically bonded to a poly(dimethylsiloxane)) was employed for the separation of enantiomers by capillary supercritical fluid chromatography and gas chromatography. In SFC, the dependence of the retention bebavior (k') and chiral separation factors (a) on applied pressure, density, and analysis temperature has been investigated for the two representative chiral test solute I-phenylethanol and camphor. Even at high densities of the carbon dioxide mobile phase, the enantioselectivities measured at low temperatures under supercritical conditions were found to be similar to those expected from the extrapolation high-temperature measurements in GC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::353c2a018e96b87bfdd15789a9f5ef50 https://doi.org/10.1021/ac00090a016 Zobrazit plný text záznamu