Altered Purkinje cell responses and calmodulin expression in the spontaneously ataxic mouse, Pogo

Autor:	Young Gil Jeong, Se Hoon Kim, Jin Seong Kim, Kwan Young Lee, Dong Kwan Kim, Hyung Seo Park, Nam-Seob Lee
Rok vydání:	2011
Předmět:	medicine.medical_specialty Cerebellum Ataxia Calmodulin biology General Neuroscience Purkinje cell Parallel fiber Hindlimb medicine.anatomical_structure Endocrinology nervous system Internal medicine medicine biology.protein Ataxic Gait medicine.symptom Long-term depression Neuroscience
Zdroj:	European Journal of Neuroscience. 33:1493-1503
ISSN:	0953-816X
DOI:	10.1111/j.1460-9568.2011.07641.x
Popis:	Ataxia is often associated with altered cerebellar motor control, a process in which Purkinje cells (PCs) play a principal role. Pogo mice display severe motor deficits characterized by an ataxic gait accompanying hindlimb hyperextension. Here, using whole-cell patch-clamp recordings, we show that parallel fiber (PF)-excitatory post-synaptic currents (PF-EPSCs) are reduced, paired-pulse facilitation (PPF) is increased and PF-PC long-term depression (LTD) is impaired in Pogo mice; in contrast, climbing-fiber EPSCs are preserved. In control mice, treatment with the calmodulin antagonist calmidazolium (5 μm) impaired PPF and LTD. Notably, cerebellar calmodulin expression was significantly reduced in Pogo mice compared with control mice. Control PCs predominantly exhibited a tonic firing pattern, whereas the firing pattern in Pogo PCs was mainly a complex burst type. These results implicate alterations in PC responses and calmodulin content in the abnormal cerebellar function of Pogo mice.
Databáze:	OpenAIRE
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