Synthesis and Molecular Docking Study of Novel Chromeno-chromenones as Anti-HIV-1 NNRT Inhibitors

Autor:	Suresh C. Jadhavar, Hanmant M. Kasralikar, Sudhakar R. Bhusare
Rok vydání:	2015
Předmět:	Indole test Anti hiv 1 chemistry.chemical_compound Barbituric acid Salicylaldehyde chemistry 4-Hydroxycoumarin Organic Chemistry Proline Condensation reaction Coumarin Combinatorial chemistry
Zdroj:	Synlett. 26:1969-1972
ISSN:	1437-2096 0936-5214
DOI:	10.1055/s-0034-1381043
Popis:	l -Proline has been employed efficiently for the synthesis of chromeno-chromenone derivatives via a one-pot, three component condensation reaction of salicylaldehydes, 4-hydroxy coumarin, and indole or barbituric acid. The simple procedure and good to excellent yields (78–90%) are notable features of the method. The obtained derivatives were studied for their molecular docking as an anti-HIV-1 RT.
Databáze:	OpenAIRE
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