#14: Blastomycosis in 64 Wisconsin Children: Unanticipated Infection Risk and Severity in Urban Residents
| Autor: | Jaimee M Hall, Peter L. Havens, Errin A. Mitchell, Michelle Mitchell, Pippa Simpson, Sue C Kehl, Michael J. Chusid, Kelly J. Henrickson, Anna R. Huppler, Lauren L. Titus, Mahua Dasgupta, Rodney E. Willoughby, Gabriel N. De Vela |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Infection risk Lung business.industry General Medicine Environmental exposure medicine.disease Infectious Diseases medicine.anatomical_structure Pediatrics Perinatology and Child Health Emergency medicine Severity of illness medicine Immunocompetence business Blastomycosis |
| Zdroj: | Journal of the Pediatric Infectious Diseases Society. 10:S8-S8 |
| ISSN: | 2048-7207 |
| Popis: | Background Blastomycosis is an endemic mycosis of immunocompetent individuals, typically seen after exposure to wooded areas near rivers, lakes, and streams in rural locations, and often not considered a disease of urban environments. Disease can be isolated to lung, or disseminate to skin, bone, or central nervous system. Factors influencing disease acquisition and severity in children are unknown. Methods We analyzed acquisition risk factors and disease characteristics of blastomycosis in children treated at a tertiary care center from 1998–2018 to identify exposure source and measure disease severity, to identify cases without “typical exposure”, and to measure the effect of race on disease severity. Results Of 64 children, median age was 13.3 years, 72% were male, 38% resided in urban counties, and 50% had typical environmental exposure. Isolated pulmonary infection occurred in 33 (52%). The remaining children had evidence of dissemination including skin (N=13), bone (N=16; 7 clinically silent), and central nervous system (N=7; 3 clinically silent). Infection was moderate/severe in 19 (30%). Two children (3%) died. 79% of children with moderate/severe disease (p=0.008) and 71% of urban children (p=0.007) had no typical environmental exposure. Comparing children from urban counties to other residences, 63% versus 5% were black (p Conclusions Blastomycosis, endemic in urban children in the absence of typical exposure history, has frequent, sometimes clinically silent, extrapulmonary dissemination, with a trend toward more severe disease in black children. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |