A fluorescent probe based on Ir(III) solvent complex for specific recognition of histidine in aqueous solution and the application in cell imaging

Autor:	Le Zhou, Xuebin Shen, Di Li, Hui Wang, Lei Hu, Hao Chen, Bingsong Xu, Yongling Xu, Fengze Cai
Rok vydání:	2020
Předmět:	Aqueous solution Combinatorial chemistry Fluorescence Inorganic Chemistry Solvent chemistry.chemical_compound chemistry Cytoplasm Materials Chemistry Physical and Theoretical Chemistry Solubility Luminescence Derivative (chemistry) Histidine
Zdroj:	Inorganica Chimica Acta. 511:119799
ISSN:	0020-1693
DOI:	10.1016/j.ica.2020.119799
Popis:	To develop novel fluorescent probes for detecting endogenous histidine (His) plays significant roles in physiological and pathological fields. Herein, a non-emissive Ir(III) complex [Ir(C–N)2(CH3CN)2]+NO3− (IrCN, C–N represents 2-phenylpyridine derivative) has been demonstrated to be a reaction-based fluorescent probe for the recognition of His in HEPES buffer. It is found that IrCN can selectively detect His with a distinct “turn-on” luminescence and low limit of detection (LOD = 0.62 μM), relying on which, IrCN can light-up the cytoplasm and nuclear region of the fixed cells, exhibiting negligible cytotoxicity and suitable solubility under test concentration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::352f7a738ab9008d9625365e6ad8213e https://doi.org/10.1016/j.ica.2020.119799 Zobrazit plný text záznamu Full Text from ScienceDirect