| Autor: |
Dinh Chau Phan, Binh Duong Vu, Thi Hong Tham Nguyen, Thi Hong Thanh Nguyen, Quang Anh Luong, Thi Xuan Thu Ngo |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Letters in Organic Chemistry. 20:672-677 |
| ISSN: |
1570-1786 |
| DOI: |
10.2174/1570178620666230123094019 |
| Popis: |
Abstract: Memantine hydrochloride (MH) is a first-line therapeutic drug approved by the US FDA for the management of moderate to severe Alzheimer's disease. This study involves the synthesis of memantine hydrochloride from 1-bromo-3,5-dimethyladamantane through a reaction with thiourea. The research results showed that the solvent reaction was propylene glycol (PG); the total time reaction was 5.5 hours, the temperature reaction in the first stage was 160oC and in the second stage was 80oC; the overall yield was 82.44%. The reaction intermediates were confirmed by the IR, MS,1HNMR, and 13C-NMR spectra. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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