Oxygen Alkylation of Schiff Base Derivatives of Amino Acids

Autor:	Martin J. O'Donnell, David B. Rusterholz, Gwendolyn K. Cook
Rok vydání:	1991
Předmět:	chemistry.chemical_classification Schiff base Dipeptide Organic Chemistry Imine Alkylation Medicinal chemistry Catalysis Amino acid chemistry.chemical_compound chemistry Benzophenone Saponification Alkyl
Zdroj:	Synthesis. 1991:989-993
ISSN:	1437-210X 0039-7881
DOI:	10.1055/s-1991-26625
Popis:	Higher imine esters 1a-h and 7a-b of amino acids and dipeptides are prepared in 68-91 % yield by saponification of the benzophenone Schiff base methyl esters 3a-d and 6 using phase-transfer techniques followed by O-alkylation with an alkyl halide. The procedure occurs with retention of configuration at the α-carbon except with phenylglycine derivatives
Databáze:	OpenAIRE
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