C-peptide level concomitant with hypoglycemia gives better performances than insulin for the diagnosis of endogenous hyperinsulinism: a single-center study of 159 fasting trials
| Autor: | Fidéline Bonnet-Serrano, Clara Devin-Genteuil, Louis Thomeret, Christelle Laguillier-Morizot, Marie-Clémence Leguy, Anna Vaczlavik, Lucas Bouys, Corinne Zientek, Léopoldine Bricaire, Laura Bessiène, Laurence Guignat, Rossela Libé, Helen Mosnier-Pudar, Guillaume Assié, Lionel Groussin, Jean Guibourdenche, Jérôme Bertherat |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | European Journal of Endocrinology. 188 |
| ISSN: | 1479-683X 0804-4643 |
| Popis: | IntroductionDiagnosis of endogenous hyperinsulinism relies on the occurrence of a hypoglycemia, concomitant with inadequate high insulin and C-peptide levels. However, diagnostic cutoffs are not consensual among the different learned societies. The objective of this work was to propose optimized cutoffs for these three parameters for the diagnosis of endogenous hyperinsulinism.MethodsAll the patients having performed a fasting trial in Cochin Hospital Endocrinology Department between February 2012 and August 2022 were included. The results of glycemia, insulin and C-peptide levels during fasting trial were collected and analyzed.ResultsOne hundred and fifty-nine patients were included: 26 with endogenous hyperinsulinism and 133 without endogenous hyperinsulinism. ROC analysis of glycemia nadir during fasting trial identified the value of 2.3 mmol/L as the optimal cutoff, ensuring a sensitivity of 100% associated with a specificity of 81%. ROC analysis of insulin and C-peptide levels concomitant with hypoglycemia ConclusionA C-peptide level 0.3 nmol/L concomitant with a hypoglycemia |
| Databáze: | OpenAIRE |
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