| Autor: |
Kristen Frenzel, Kenneth E. Bernstein, Sebastien Fuchs, Justin M. Cole, Hong D. Xiao |
| Rok vydání: |
2003 |
| Předmět: |
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| Zdroj: |
The American Journal of Pathology. 163:807-817 |
| ISSN: |
0002-9440 |
| DOI: |
10.1016/s0002-9440(10)63441-4 |
| Popis: |
Virtually all scientists are aware of the tremendous progress in genetic modeling brought about by targeted homologous recombination in embryonic stem cells. Often called a “knockout mouse”, the ability to modify the mouse genome has created animal models for a large number of disease processes. Typically, targeted genetic modifications are used to inactivate a gene resulting in a mouse null for the corresponding protein. While this approach has been tremendously useful, the most recent work in this area makes use of more subtle genetic modifications to probe the functional role of a protein in an organ-specific or developmental fashion. This review will touch on work from my group and several other laboratories that are using newer approaches to gene targeting with the goal of creating mouse models that ask questions not addressable through the simple inactivation of a gene. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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