Interferon retreatment in chronic hepatitis C
| Autor: | Nicoletta Sinelli, I. Ponassi, Renata Brizzolara, A. G. Cipriani, Francesco Torre, G. Marenco, P. De Leo, Antonio Picciotto, G. Varagona, V. De Conca, S. Mesiti, A. Grasso, Dodero M, G. Menardo, Guido Celle, N. Campo |
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| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
Hepatology biology business.industry medicine.medical_treatment Hepatitis C virus Hepacivirus education Gastroenterology Alpha interferon Retrospective cohort study Immunotherapy medicine.disease_cause biology.organism_classification humanities Flaviviridae Alanine transaminase Internal medicine Immunology medicine biology.protein Viral disease business |
| Zdroj: | European Journal of Gastroenterology & Hepatology. 11:649-654 |
| ISSN: | 0954-691X |
| DOI: | 10.1097/00042737-199906000-00011 |
| Popis: | UNLABELLED OBJECTIVE; To evaluate the results of a large cohort of non-responder or relapsing responder patients with chronic hepatitis C retreated with various schedules of interferon (IFN). METHODS Our study included 276 patients (158 non-responders and 118 relapsing responders) who underwent IFN retreatments. Among the non-responder group, 158 patients underwent further courses of IFN. In particular, 108 patients underwent one course of IFN retreatment, 40 patients underwent two courses, eight patients underwent three courses, and two patients underwent four courses. Regarding the relapsing responder group, the 118 patients were retreated with the same dosage for varying periods. In particular, 50 patients were treated for 6 months, 43 patients for 12 months, and 25 for 24 months. Patients in the subgroups of IFN retreatment were homogeneous as far as age and gender distribution, as well as virological and histological characteristics, are concerned. Qualitative and quantitative HCV-RNA was evaluated at baseline, at the end of treatment and at the last check-up of follow-up. HCV genotype was determined on baseline serum samples. Alanine transaminase (ALT) levels were tested monthly. RESULTS Long-term biochemical (normal ALT levels) and virological (HCV-RNA negative) response was obtained in 2.6% of non-responder retreated patients, and in 33.9% of relapsing responder retreated patients. Evaluation of response on the basis of the duration of treatment showed that 48%, 19% and 16% of relapsing responder patients retreated for 24, 12 and 6 months, respectively, obtained long-term biochemical and virological response. CONCLUSION Non-responder patient retreatment is inefficient especially in cirrhotic and/or genotype 1 b patients. IFN retreatment is warranted in relapsing responder patients. In particular, 24-month therapy induces significant long-term biochemical and virological response. |
| Databáze: | OpenAIRE |
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