Predicting recognition between T cell receptors and epitopes using contextualized motifs
| Autor: | Emmi Jokinen, Alexandru Dumitrescu, Jani Huuhtanen, Vladimir Gligorijević, Satu Mustjoki, Richard Bonneau, Markus Heinonen, Harri Lähdesmäki |
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| Rok vydání: | 2022 |
| Popis: | We introduce TCRconv, a deep learning model for predicting recognition between T-cell receptors and epitopes. TCRconv uses a deep protein language model and convolutions to extract contextualized motifs and provides state-of-the-art TCR-epitope prediction accuracy. Using TCR repertoires from COVID-19 patients, we demonstrate that TCRconv can provide insight into T-cell dynamics and phenotypes during the disease. |
| Databáze: | OpenAIRE |
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