Effects of ?-endorphin on the development of denervation changes in rat muscle fiber membrane

Autor: Chikin Av, A. Kh. Urazaev, Volkov Em, Poletaev Gi, Kh. S. Khamitov
Rok vydání: 1988
Předmět:
Zdroj: Neurophysiology. 19:550-555
ISSN: 1573-9007
0090-2977
DOI: 10.1007/bf01056920
Popis: Recordings were made of post-denervation changes in resting potential and input resistance in muscle fiber membrane, as well as anode break, tetrodotoxin resistant action potentials, and asynaptic sensitivity to acetylcholine during experiments on cultured diaphragm muscle fiber isolated from rats. Addition of β-endorphin to the culture medium prevented increase in the input resistance of muscle fibers and reduced development of asynaptic transmitter sensitivity in the membrane, but failed to change the ability of the denervated muscle membrane to generate anode break and tetrodotoxin-resistant action potentials. The effects of β-endorphin were not abolished by naloxone, which itself had endorphin-like powers as measured by the indices used in this research. It is therefore suggested that β-endorphin or like substances could be claimed as the neurotrophic factors responsible for controlling passive electrical properties of the muscle fiber membrane and contribute to regulating its acetylcholine sensitivity.
Databáze: OpenAIRE
Externí odkaz: