DIAGNOSTIC ACCURACY OF 68Ga-PSMA PET/MRI AND MULTIPARAMETRIC MRI IN DETECTING INDEX TUMOR IN RADICAL PROSTATECTOMY SPECIMEN
| Autor: | Ümit Özgür Akdemir, Uğuray Aydos, Lütfiye Özlem Atay, Nil Tokgöz, İlker Şen, Murat Ucar, Uğur Coşar, İpek Işık Gönül, Murat Yavuz Koparal, Sinan Sözen |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.diagnostic_test
business.industry Prostatectomy medicine.medical_treatment Multiparametric MRI Magnetic resonance imaging Diagnostic accuracy medicine.disease Likelihood ratios in diagnostic testing Prostate cancer medicine.anatomical_structure Prostate Positron emission tomography medicine Nuclear medicine business |
| Popis: | Objective To evaluate the diagnostic accuracy of the 68Gallium (68Ga) - prostate specific membrane antigen (PSMA) positron emission tomography/magnetic resonance imaging (PET/MRI) and multiparametric MRI (mpMRI) by region-based comparison of index tumour localisations using histopathological tumour maps of patients who underwent radical prostatectomy due to clinically significant prostate cancer. Patients and Methods The study included 64 patients who underwent radical prostatectomy after primary staging with mpMRI and 68Ga-PSMA PET/MRI. Diagnostic analysis was performed by dividing the prostate into four anatomic regions as left/right anterior and left/right posterior. The extension of the lesions in mpMRI and the pathological uptake in 68Ga-PSMA PET/MRI were matched separately for each region with the extension of the index tumour into each region. Results The sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, negative likelihood ratio, and the accuracy of mpMRI and 68Ga-PSMA PET/MRI are shown as 55.7%, 91.8%, 80.6%, 77.2%, 78.1% and 60.8%, 94.3%, 86.8% 79.8%, 83.5%, respectively. 68Ga-PSMA PET/MRI has higher sensitivity and specificity compared with mpMRI. However, no statistically significant difference was found (p = 0.464). Combined imaging had significantly higher diagnostic accuracy compared with mpMRI and 68Ga-PSMA PET/MRI (change in AUC: 0.084 and 0.046, p < 0.001 and p = 0.028, respectively), while no statistically significant difference was found between mpMRI and 68Ga-PSMA PET/MRI (change in AUC: 0.038, p = 0.246). Conclusion 68Ga-PSMA PET/MRI had higher clinical diagnostic accuracy in prostate cancer compared with mpMRI. Diagnostic accuracy was significantly increased in the combined use of both imaging modalities. |
| Databáze: | OpenAIRE |
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