| Autor: | O. A. Azizova, S. V. Drinitsyna, A. V. Aseichev, L. B. Dudnik, Yu. M. Lopukhin, N. P. Solov'eva, M. A. Pokrovskaya, I. L. Pogoretskaya, A. P. Savchenkova |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
High concentration
medicine.medical_specialty Chemistry General Medicine Fibrinogen General Biochemistry Genetics and Molecular Biology Coronary heart disease In vitro Lipid peroxidation chemistry.chemical_compound Endocrinology Biochemistry Internal medicine Blood plasma Plasma lipids medicine lipids (amino acids peptides and proteins) In patient medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 135:29-33 |
| ISSN: | 0007-4888 |
| Popis: | In patients with coronary heart disease oxidizability of lipids during Cu2+-induced oxidation of blood plasma inversely correlated with fibrinogen content. A positive correlation was found between the amount of lipid peroxidation products in the plasma from these patients and fibrinogen content. The increase in fibrinogen content was associated with high levels of total lipids and triglycerides and low concentration of high-density lipoprotein cholesterol. In vitro experiments demonstrated that fibrinogen reduces oxidizability of blood plasma. Our results suggest that the decrease in lipid oxidizability at high concentration of fibrinogen in patients with coronary heart disease is related to predominant oxidation of fibrinogen and its competition with plasma lipids during Cu2+-induced oxidation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink