Polysorbate 80 Coated Solid Lipid Nanoparticles for the Delivery of Temozolomide Into the Brain
| Autor: | Pawan Yadav, Ranjit Singh, Amit Goyal, Gazal Sharma, Goutam Rath |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pharmacology Temozolomide Chemistry Pharmaceutical Science Blood–brain barrier Polyvinyl alcohol Brain targeting 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis Drug Discovery Solid lipid nanoparticle medicine Molecular Medicine medicine.drug |
| Zdroj: | The Open Pharmacology Journal. 8:21-28 |
| ISSN: | 1874-1436 |
| DOI: | 10.2174/1874143601808010021 |
| Popis: | Introduction:Anti-angiogenic therapy can produce transient regression in tumor in case of Glioblastoma (GBM); however, no prolongation of patient survival rate had so far been achieved.Methodology:To address this problem, an effort was made to design and characterize a temozolomide loaded nanosystem for targeting the tumor vasculature in the brain using polymeric nanoparticles. It included the formation of Temozolomide (TMZ) loaded Solid-Lipid Nanoparticles (SLNs) and their conjugation with polysorbate-80 (P-80) which enhanced the penetration of drug to blood-brain barrier resulting in the enhancement of pro-apoptotic activity.Results:Conjugating nanoparticles with a tumor-penetrating polymer (P-80) further enhanced the therapeutic efficacy of the drug.Conclusion:The animal studies indicated the enhanced potential of the developed system in the effective treatment of glioblastoma. |
| Databáze: | OpenAIRE |
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