Optimized Marker System for Early Diagnosis of Breast Cancer

Autor:	Eleonora A. Braga, A. M. Burdennyy, S S Lukina, I. V. Pronina, Vitaly I. Loginov, Tatiana P. Kazubskaya, N A Ivanova, D. S. Khodyrev, E. A. Filippova
Rok vydání:	2021
Předmět:	Oncology medicine.medical_specialty business.industry Normal tissue General Medicine Methylation medicine.disease General Biochemistry Genetics and Molecular Biology Breast cancer Paired samples Internal medicine microRNA medicine business Gene
Zdroj:	Bulletin of Experimental Biology and Medicine. 172:57-62
ISSN:	1573-8221 0007-4888
Popis:	Changes in the methylation levels of 21 microRNA genes in 91 breast cancer samples in comparison with paired samples of histologically unchanged tissue were studied by quantitative methylation-specific PCR. For 19 microRNA genes, a significant increase in the methylation level in tumors in comparison with normal tissues was shown (Mann-Whitney test). When considering the data for breast cancer samples only from patients with clinical stages I and II (59samples), 17 genes with a significantly increased level of methylation were identified. Increased methylation level for 11 genes (MIR124-1, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR132, MIR137, MIR193a, MIR34B/C, MIR375, and MIR9-1) compared to the paired norm was highly significant (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3502e9c629fab3bec5f7ba78243f6254 https://doi.org/10.1007/s10517-021-05331-z Zobrazit plný text záznamu Full text from SpringerLink