Synthesis of Protein Conjugates of 2-Carboxy-L-Arabinitol 5-Phosphate and 2-Carboxy-L-Ribitol 5-Phosphate

Autor:	Andrée Marquet, Nelly Gourlaouën, Dominique Florentin
Rok vydání:	1998
Předmět:	biology Stereochemistry Organic Chemistry Phosphate Biochemistry Pyrophosphate Catalysis chemistry.chemical_compound chemistry biology.protein L-arabinitol Bovine serum albumin Hapten Ribitol-5-phosphate Conjugate
Zdroj:	Journal of Carbohydrate Chemistry. 17:1219-1238
ISSN:	1532-2327 0732-8303
DOI:	10.1080/07328309808001895
Popis:	The synthesis of 5-O-[5-(pentanoic acid)]-phosphono-L-erythro-pent-2-ulose 2 was successfully achieved by coupling benzyl 5-hydroxypentanoate 9b and 1-O-benzyl-L-erythro-pent-2-ulose ethane- 1,2-diyl dithioacetal 13 with the enediol pyrophosphate 18. Compound 2 was coupled to carrier proteins, porcine thyroglobuline and bovine serum albumin and the conjugates were treated with KCN to give conjugates of the hapten 1, designed to raise catalytic antibodies.
Databáze:	OpenAIRE
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