Some Features of the Tscherniac‒Einhorn Reaction with 2-Thiouracil Derivatives

Autor:	Dmitry S. Sheikin, A. Yu. Maryshev, A. S. Babushkin, Dominique Schols, V. V. Chapurkin, Ivan A. Novakov, M. B. Navrotskii, Evsey A. Ruchko
Rok vydání:	2020
Předmět:	endocrine system Trifluoromethyl 010405 organic chemistry General Chemistry Alkylation 010402 general chemistry 01 natural sciences Medicinal chemistry Decomposition Thiouracil 0104 chemical sciences Catalysis Phthalimide chemistry.chemical_compound chemistry In vitro study Cytotoxicity
Zdroj:	Russian Journal of General Chemistry. 90:352-356
ISSN:	1608-3350 1070-3632
DOI:	10.1134/s1070363220030056
Popis:	The Tscherniac–Einhorn reaction of 6-methyl and 6-(trifluoromethyl) derivatives of 2-thiouracil with N-(bromomethyl)phthalimide in under basic catalysis leads to the formation of S-amidomethylation products. When using 6-amino-2-thiouracil, decomposition of the alkylation products occurs. An in vitro study of the compounds obtained showed their lack of cytotoxicity and anti-HIV-1/2 activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::34fc8faa527b35aafc0cca4c05f1ae52 https://doi.org/10.1134/s1070363220030056 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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