The countermeasure for Zika virus: a hard nut to be cracked

Autor:	Komal Saleem, Aleena Sumrin, Muhammad Bilal, Sana Usman, Hamid Bashir, Zara Naz
Rok vydání:	2018
Předmět:	0301 basic medicine Nut 03 medical and health sciences 030104 developmental biology Countermeasure biology Virology biology.organism_classification Zika virus
Zdroj:	Future Virology. 13:361-369
ISSN:	1746-0808 1746-0794
Popis:	The emergence of Zika virus (ZIKV) infection in America has caused a new threat worldwide, as it is linked with the increased incidence of congenital microcephaly in neonates and development of Guillain–Barré syndrome. A number of potential antiviral drugs such as sofosbuvir, BCX4430, NITD008 and 7-DMA have shown activity against ZIKV both in vitro and in vivo. Similarly, different research organizations and academic institutions are trying hard to develop a vaccine against the ZIKV. Some of these groups have received approval from the US FDA to start Phase I clinical trials. Immuno-based treatment strategies, such as use of humanized monoclonal antibodies (hE16 and CR4373) have also entered clinical trials. However, a licensed vaccine is still a long way off and efforts should be made to accelerate the evaluation procedures while minimizing the delay in licensing.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::34f50514057376618a1694ba06ce4e7e https://doi.org/10.2217/fvl-2018-0018 Zobrazit plný text záznamu