Radiomic features of primary tumor by lung cancer stage: analysis in BRAF mutated non-small cell lung cancer
| Autor: | Subba R. Digumarthy, Ibiayi Dagogo-Jack, Mannudeep K. Kalra, Ramandeep Singh, Eric W. Zhang, Dexter P. Mendoza, Atul Padole |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Receiver operating characteristic Tumor size business.industry Cancer medicine.disease Primary tumor 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Oncology 030220 oncology & carcinogenesis Hounsfield scale medicine Radiology Non small cell Stage (cooking) Lung cancer business |
| Zdroj: | Translational Lung Cancer Research. 9:1441-1451 |
| ISSN: | 2226-4477 2218-6751 |
| Popis: | Background The clinical features and traditional semantic imaging characteristics of BRAF-mutated non-small cell lung cancer (NSCLC) have been previously reported. The radiomic features of BRAF-mutated NSCLC and their role in predicting cancer stage, however, have yet to be investigated. This study's goal is to assess the differences in CT radiomic features of primary NSCLC driven by BRAF mutation and stratified by tumor-node-metastasis (TNM) staging. Methods Our IRB approved study included 62 patients with BRAF mutations (V600 in 27 and non-V600 in 35 patients), who underwent contrast-enhanced chest CT. Tumor stage was determined based on the 8th edition of TNM staging. Two thoracic radiologists assessed the primary tumor imaging features such, including tumor size (maximum and minimum dimensions) and density (Hounsfield units, HU). De-identified transverse CT images (DICOM) were processed with 3D slicer (Version 4.7) for manual lesion segmentation and estimation of radiomic features. Descriptive statistics, multivariate logistic regression, and receiver operating characteristics (ROC) were performed. Results There were significant differences in the radiomic features based on cancer stages I-IV with the most significant differences between stage IV and stage I lesions [AUC 0.94 (95% CI: 0.86-0.99), P |
| Databáze: | OpenAIRE |
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