Enhanced biocompatibility of GPC by ion implantation and deposition

Autor:	Robert Lee Zimmerman, F. Ozdal-Kurt, Claudiu Muntele, Daryush Ila, Ismet Deliloglu Gurhan, B.H. Sen, Marcos Rodrigues
Rok vydání:	2007
Předmět:	Materials science Biocompatibility Ion beam Surfaces and Interfaces General Chemistry Adhesion Condensed Matter Physics Biocompatible material Surfaces Coatings and Films Ion implantation Materials Chemistry Oxygen ions Deposition (phase transition) Cell adhesion Biomedical engineering
Zdroj:	Surface and Coatings Technology. 201:8020-8023
ISSN:	0257-8972
DOI:	10.1016/j.surfcoat.2006.09.317
Popis:	Biocompatible Glassy Polymeric Carbon (GPC) is used for artificial heart valves and in other biomedical applications. Although it is ideally suited for implants in the blood stream, tissue that normally forms around the moving parts of a GPC heart valve sometimes loses adhesion and creates embolisms downstream. We have previously shown that oxygen ion implantation slightly enhances cell adhesion to GPC. Here we compare silver ion implantation and silver deposition, each of which strongly inhibits cell attachment on GPC. Inhibition of cell adhesion is the more desirable improvement to current GPC cardiac implants. In vitro biocompatibility tests have been carried out with model cell lines to demonstrate that traces of silver can favorably influence the surface of GPC for biomedical applications.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::34e52626aa8122c0ac6ac92586a7aa7f https://doi.org/10.1016/j.surfcoat.2006.09.317 Zobrazit plný text záznamu Full Text from ScienceDirect