Leptin hormone level in serum of opticospinal, neuromyelitisoptica and multiple sclerosis patients

Autor:	Sayyed Hamid Zarkesh-Esfahani, Masoud Etemadifar, Alexa Triot, Majid Bouzari, Amir H. Maghzi, Mohammad Taghi Kardi, Maryam Mostajeran, Ehsan Bahrami
Rok vydání:	2014
Předmět:	medicine.medical_specialty Expanded Disability Status Scale Neuromyelitis optica business.industry Multiple sclerosis Leptin medicine.medical_treatment digestive oral and skin physiology Immunology Central nervous system Neuroscience (miscellaneous) medicine.disease Pathogenesis Endocrinology Cytokine medicine.anatomical_structure Immunology and Microbiology (miscellaneous) Internal medicine Medicine Neurology (clinical) business hormones hormone substitutes and hormone antagonists Hormone
Zdroj:	Clinical and Experimental Neuroimmunology. 5:77-83
ISSN:	1759-1961
DOI:	10.1111/cen3.12092
Popis:	Objectives A growing body of evidence shows that leptin acts as a pro-inflammatory cytokine in autoimmune disorders and is related to multiple sclerosis (MS) pathogenesis. The present study was an analysis of serum leptin levels among healthy volunteers and patients with different subtypes of MS, opticospinal MS (OSMS) and neuromyelitis optica (NMO). Methods Leptin concentrations in the sera of 121 healthy volunteers and 201 patients with different subtypes of MS, as well as in 27 NMO and 27 OSMS, were measured. Results Significant differences in leptin serum levels were observed between healthy volunteers, and MS, OSMS and NMO patients (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::34ddfbbe02d360ff8ec7618a6b5a4261 https://doi.org/10.1111/cen3.12092 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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