Low folate metabolic stress reprograms DNA methylation-activated sonic hedgehog signaling to mediate cancer stem cell-like signatures and invasive tumour stage-specific malignancy of human colorectal cancers
| Autor: | Jhuan-Yu Lin, Hsin-Chun Feng, Chang-Sheng Kuo, Shu-Han Hsu, Yu-Feng Tian, Ding-Ping Sun, Wen-Yu Lan, Rwei-Fen Syu Huang |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cancer Research Cyclopamine biology Hedgehog signaling pathway 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Oncology chemistry SOX2 Cancer stem cell GLI1 030220 oncology & carcinogenesis embryonic structures DNA methylation Immunology biology.protein Cancer research Sonic hedgehog Reprogramming |
| Zdroj: | International Journal of Cancer. 141:2537-2550 |
| ISSN: | 0020-7136 |
| DOI: | 10.1002/ijc.31008 |
| Popis: | The mechanistic role of colonic low folate metabolic stress (LFMS) in colorectal cancer (CRC) malignancy development remains unknown. Folate analysis on the 99 paired human CRC tissues localized LFMS to the deep invasive T3/T4 staged tumours with hypo-methylated sonic hedgehog (Shh) promoter region and amplified expressions of Shh ligand and Gli1 effectors, which coincided with deregulated expressions of the epithelial-mesenchymal transition (EMT) mediators. Colonic folate levels of CR were inversely correlated with pluripotent expressions of the SOX2, NANOG and OCT4 markers (P |
| Databáze: | OpenAIRE |
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