Changes in the histostructure of the lungs of old rats under conditions of persistent hyperhomocysteinemia
| Autor: | I. A. Samborska |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Hyperhomocysteinemia COPD Pathology medicine.medical_specialty Reactive oxygen species Homocysteine business.industry Atelectasis medicine.disease Lipid peroxidation chemistry.chemical_compound chemistry Blood plasma medicine General Earth and Planetary Sciences Respiratory system business General Environmental Science |
| Zdroj: | Biomedical and Biosocial Anthropology. :41-45 |
| ISSN: | 2616-6208 1816-031X |
| Popis: | To date, homocysteine has been found to be an important biomarker of bronchopulmonary pathology, including COPD. The increase in its concentration in the blood plasma causes the start of free radical processes and the production of reactive oxygen species, which activate lipid peroxidation in lung tissue. In addition, the activation of endoplasmic reticulum stress with increasing homocysteine levels is the main reason for triggering apoptosis of alveolocytes. The aim of the research is to study the features of lungs histostructure in old rats under conditions of hyperhomocysteinemia. The experimental study was performed on 20 white nonlinear old (24-26 months) male rats. During the experiment, the animals were divided into two groups – control and experimental. Simulation of the state of persistent hyperhomocysteinemia was achieved by administering to rats of experimental group thiolactone homocysteine at a dose of 200 mg/kg body weight intragastrally for 60 days. Histological specimens were studied using an SEO CCAN light microscope and photo-documented using a Vision CCD Camera with an image output system from histological specimens. In elderly animals under conditions of experimental hyperhomocysteinemia develop severe destructive-degenerative changes in the lungs. Significant remodeling of the vascular bed, bronchi, inflammatory manifestations, enlargement of dis- and atelectasis and emphysematically altered alveoli of the respiratory lungs, violation of the alveolar walls, with the release of blood cells into the alveolar space and the formation of small diapedetic hemorrhages. The development of perivascular, peribronchial and interstitial sclerosis is characteristic. |
| Databáze: | OpenAIRE |
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