| Autor: |
Gabriel Viennet, Pascale Varlet, Dominique Figarella-Branger, Anh Tuan Nguyen, Clovis Adam, Dominique Cazals-Hatem, Karima Mokhtari, Henri Sevestre, Fabien Forest, François Labrousse, Catherine Carpentier, Sandrine Eimer, Valérie Rigau, Danchristian Chiforeanu, Marie-Hélène Aubriot-Lorton, Carole Colin, Sophie Michalak, F. Vandenbos, Marie-Claire Tortel, Marie-Pierre Chenard, Annie Laquerrière, Isabelle Quintin-Roue, Pomone Richard, Anne Heitzmann, Delphine Loussouarn, Jean Louis Kemeny, Jean-Yves Delattre, Jean-Michel Vignaud, Caroline Dehais, Anne Jouvet, Emmanuelle Uro-Coste, Chiara Villa, Marie-Danièle Diebold, Pierre-Marie Levillain, Marc Polivka, Emmanuelle Lechapt-Zalcman, Claude-Alain Maurage |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Brain Pathology. 25:418-428 |
| ISSN: |
1015-6305 |
| Popis: |
Diffuse adult high-grade gliomas (HGGs) with necrosis encompass anaplastic oligodendrogliomas (AOs) with necrosis (grade III), glioblastomas (GBM, grade IV) and glioblastomas with an oligodendroglial component (GBMO, grade IV). Here, we aimed to search for prognostic relevance of histological classification and molecular alterations of these tumors. About 210 patients were included (63 AO, 56 GBM and 91 GBMO). GBMO group was split into "anaplastic oligoastrocytoma (AOA) with necrosis grade IV/GBMO," restricted to tumors showing intermingled astrocytic and oligodendroglial component, and "GBM/GBMO" based on tumors presenting oligodendroglial foci and features of GBM. Genomic arrays, IDH1 R132H expression analyses and IDH direct sequencing were performed. 1p/19q co-deletion characterized AO, whereas no IDH1 R132H expression and intact 1p/19q characterized both GBM and GBM/GBMO. AOA with necrosis/GBMO mainly demonstrated IDH1 R132H expression and intact 1p/19q. Other IDH1 or IDH2 mutations were extremely rare. Both histological and molecular classifications were predictive of progression free survival (PFS) and overall survival (OS) (P < 10(-4) ). Diffuse adult HGGs with necrosis can be split into three histomolecular groups of prognostic relevance: 1p/19q co-deleted AO, IDH1 R132H-GBM and 1p/19q intact IDH1 R132H+ gliomas that might be classified as IDH1 R132H+ GBM. Because of histomolecular heterogeneity, we suggest to remove the name GBMO. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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