Soma-germ line interactions and a role for muscle in the regulation ofC. eleganssperm motility
| Autor: | Gillian M. Stanfield, Daniela R Chavez, Joseph R. Smith, Angela K. Snow |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
endocrine system Gonad biology urogenital system Cellular differentiation biology.organism_classification Oocyte Sperm Sexual reproduction Cell biology 03 medical and health sciences 030104 developmental biology medicine.anatomical_structure medicine Gamete Molecular Biology Caenorhabditis elegans Sperm motility Developmental Biology |
| Zdroj: | Development. |
| ISSN: | 1477-9129 0950-1991 |
| DOI: | 10.1242/dev.167734 |
| Popis: | The development of highly differentiated sperm cells that are specialized for navigating to and fusing with an oocyte is essential for sexual reproduction. As a major part of differentiation, sperm undergo extensive post-meiotic maturation en route to the oocyte. This is regulated largely by soma-derived cues. In Caenorhabditis elegans , this process is called sperm activation, and it transforms immotile spermatids into migratory fertilization-competent cells. Here, we show that the negative regulator of sperm activation, SWM-1, is produced in an unexpected cell type: body wall muscle. SWM-1 is secreted into the body cavity and enters the gonad; there, it is present with its likely target, TRY-5, a spermiogenesis activator. We show that, in addition to SWM-1, the somatic gonad and body fluid can exchange other factors, suggesting that soma-germ line transfer could affect other reproductive processes. In addition, we show that SWM-1 may have a separate role in the sperm migratory environment, to which it is contributed by both males and hermaphrodites. These findings reveal that late stages in gamete differentiation can be regulated at the whole-organism level by broadly secreted factors. This article has an associated ‘The people behind the papers’ interview. |
| Databáze: | OpenAIRE |
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