A Rare Cause of Precocious Puberty and Massive Ovarian Cysts Associated with Hypothyroidism
| Autor: | Rachida Dafiri, Hajar El Kouarty, Nabil Moatassim Billah |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
endocrine system
medicine.medical_specialty Breast development 030219 obstetrics & reproductive medicine endocrine system diseases medicine.diagnostic_test business.industry Pelvic pain Thyroid Physical examination Bone age Abdominal distension Clitoromegaly medicine.disease Surgery 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure medicine Precocious puberty 030212 general & internal medicine medicine.symptom business |
| Zdroj: | Open Journal of Clinical Diagnostics. :1-5 |
| ISSN: | 2162-5824 2162-5816 |
| DOI: | 10.4236/ojcd.2016.61001 |
| Popis: | Van Wyk-Grumbach syndrome (VWGS) is characterized by juvenile hypothyroidism, delayed bone age, isosexual precocious puberty and massive ovarian cysts. We report such a case in a 7-year-old girl who presented with a bilateral pelvic pain, abdominal distension and signs of hypothyroidism. Physical examination showed a breast development and lack of pubic and axillary hair. There was no clitoromegaly. Pelvic ultrasonography and CT scan showed enlarged bilateral multiloculared multicystics ovarian masses. The pituitary MRI was recommended before an elevated prolactin, revealed a large sellar and suprasellar mass. The patient was started on thyroid replacement using L-Thyroxine. Clinically, the patient’s fatigue, pelvic pain, and abdominal distension are resolved. During the follow-up, her thyroid functions and serum prolactin normalized within 8 months. Ultrasonography revealed regression of ovarian cysts in 2 months measuring, with normal sized ovaries in 14 months. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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