P542 Prevalence of STIs among MSM initiating PrEP in west-africa (CohMSM-PrEP ANRS 12369 – expertise france)
| Autor: | Anoumou Dagnra, Christian Laurent, Alain Yeo, Hortense Faye-Kette, Bea Vuylsteke, Bintou Dembele, Issifou Yaya, Souba Diandé, Elias Ter Tiero Dah, Amadou Koné, Irith De Baetselier, T Crucitti, Ephrem Mensah |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
education.field_of_study GeneXpert MTB/RIF biology business.industry Obstetrics Transmission (medicine) Population biology.organism_classification medicine.disease_cause Men who have sex with men parasitic diseases Neisseria gonorrhoeae Medicine Trichomonas vaginalis business Mycoplasma genitalium education Chlamydia trachomatis |
| Zdroj: | Poster Presentations. |
| Popis: | Background Men who have sex with men (MSM) coming forward for Pre-Exposure Prophylaxis (PrEP) are at high risk for HIV and other Sexually Transmitted Infections (STIs). However, little is known about the prevalence of STIs among MSM in West-Africa. Yet, understanding the STI epidemic among MSM will improve STI management. In the framework of a PrEP demonstration study in West-Africa (CohMSM-PrEP), we tested all participants for STIs at enrollment. Methods The study was conducted in Abidjan-Cote d’Ivoire, Bamako-Mali, Lome-Togo and Ouagadougou-Burkina Faso. Participants (n=507) were tested for the following STIs using the GeneXpert instrument: Chlamydia trachomatis (CT)/Neisseria gonorrhoeae (NG) in Anorectum (A), Urine (U) and Pharynx (P), and Trichomonas vaginalis (TV) in urine. Mycoplasma genitalium (MG) was tested using the S-DiagMGTV multiplex assay in A-U-P samples. Results The overall prevalence of CT was 17.9% (19.4%, 22.0% 16.4%, and 13.6% in Lome, Abidjan, Bamako and Ouagadougou, respectively). Most CT infections were anorectal (12.3%, followed by urethral (5.7%). In Bamako, the second most infected sample type was pharyngeal (6.0%) instead of urine (5.0%). Overall prevalence of NG was 15.8% (9.7%; 25.0%; 6.0%, 22.3% in Lome, Abidjan, Bamako and Burkina, respectively). Most NG infections were found in the anorectum (10.7%), followed by the pharynx (5.7%). In Mali, no pharyngeal NG infections were detected. MG infection was 26.0% for Lome and 27.6% for Ouagadougou (results for other sites not yet available). The majority of MG infections were found in the anorectum (15.4%). Among all participants, only one urine sample with TV has been found in Bamako. Conclusion We showed a very high prevalence of extra-genital STIs among PrEP users in West-Africa. We also detected infections which would not have been treated if a syndromic management approach would have been applied (87.9%). In order to limit transmission of infections we recommend to test also extra-genital sites for STIs in this population. Disclosure No significant relationships. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|