Structure, DNA-binding interaction and antitumour activity of two novel complexes coordinated by tridentate 1,3-bis(benzimidazol-2-yl)-2-oxapropane ligand

Autor: Rong-Huan Qin, Xu-Jian Luo, Yan Yang, Yu-Lin Zhu, Yue-Xiu Jiang, Liu-Ting Yan, Wei-Jiang Liang
Rok vydání: 2013
Předmět:
Zdroj: Supramolecular Chemistry. 25:393-400
ISSN: 1029-0478
1061-0278
DOI: 10.1080/10610278.2013.792337
Popis: Two novel DNA-intercalating complexes, [Cd(hipa)(bbiop)] n (1) and [Ni(ada)(bbiop)] n ·2H2O (2) with hipa, ada and potentially tridentate ligand bbiop (bbiop, 1,3-bis(benzimidazol-2-yl)-2-oxa-propane; hipa, 5-hydroxyisophthalate; ada, aniline-N,N-diacetate), have been synthesised under hydrothermal methods and structurally characterised by single crystal X-ray diffraction analysis, elemental analysis, UV–vis spectrum and fluorescent spectrum. The bbiop ligand exists as chelating-tridentate μ1-(η3–N1, N2, O6) coordination fashion. In addition, their in vitro cytotoxicities towards four selected tumour cell lines have been evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method. Complex 1 exhibits the most dramatic inhibitory effect on MG-63, and its inhibition rate is higher than that of its free ligands, H2bbiop and hipa, indicating significantly enhanced effect after forming complex. On the basis of the combination of UV–vis absorption and fluorescence titrations, complex 1 can i...
Databáze: OpenAIRE
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