Bone Strength Estimated by Micro-Finite Element Analysis (µFEA) Is Heritable and Shares Genetic Predisposition With Areal BMD: The Framingham Study
| Autor: | Yi-Hsiang Hsu, David Karasik, Douglas P. Kiel, Steven K. Boyd, Serkalem Demissie, Ching-Ti Liu, Mary L. Bouxsein, Darlene Lu, Kerry E Broe |
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| Rok vydání: | 2017 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine medicine.medical_specialty Endocrinology Diabetes and Metabolism Population 030209 endocrinology & metabolism Genetic correlation 03 medical and health sciences 0302 clinical medicine Framingham Heart Study medicine Orthopedics and Sports Medicine Tibia Quantitative computed tomography education Femoral neck Orthodontics Bone mineral education.field_of_study medicine.diagnostic_test business.industry Heritability Surgery 030104 developmental biology medicine.anatomical_structure business |
| Zdroj: | Journal of Bone and Mineral Research. 32:2151-2156 |
| ISSN: | 0884-0431 |
| Popis: | Genetic factors contribute to the risk of bone fractures, partly because of effects on bone strength. High-resolution peripheral quantitative computed tomography (HR-pQCT) estimates bone strength using micro-finite element analysis (µFEA). The goal of this study was to investigate if the bone failure load estimated by HR-pQCT-based µFEA is heritable and to what extent it shares genetic regulation with areal bone mineral density (aBMD). Bone microarchitecture was measured by HR-pQCT at the ultradistal tibia and ultradistal radius in adults from the Framingham Heart Study (n = 1087, mean age 72 years; 57% women). Radial and tibial failure load in compression were estimated by µFEA. Femoral neck (FN) and ultradistal forearm (UD) aBMD were measured by dual-energy X-ray absorptiometry (DXA). Heritability (h2) of failure load and aBMD and genetic correlations between them was estimated adjusting for covariates (age and sex). Failure load values at the non-weight-bearing ultradistal radius and at the weight-bearing ultradistal tibia were highly correlated (r = 0.906; p |
| Databáze: | OpenAIRE |
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