α-methyl amino acids by catalytic phase-transfer alkylations

Autor:	Léon Ghosez, Mirtha Navarro, Brigitte Leclef, Jean-Pierre Antoine, Martin J. O'Donnell, Davide B. Rusterholz
Rok vydání:	1982
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Schiff base Chemistry Phase (matter) Organic Chemistry Drug Discovery Organic chemistry Alkylation Biochemistry Alkyl Amino acid Catalysis
Zdroj:	Tetrahedron Letters. 23:4259-4262
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)88719-5
Popis:	The α-methyl amino acids, α-methyl p-chlorophenylalanine, α-methyl p-tyrosine, α-methyl m-tyrosine and α-methyl DOPA have been prepared in good yields from amino ester hydrochlorides. The key step in the method is the catalytic phase-transfer alkylation of Schiff base derivatives of mono alkyl amino acids.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::34a0ab5dd217191ed7522b2c77d07520 https://doi.org/10.1016/s0040-4039(00)88719-5 Zobrazit plný text záznamu