Modification of Dietary Fiber Psyllium with Poly(vinyl pyrrolidone) through Network Formation for Use in Slow Drug Delivery Application
| Autor: | Pooja Kumari, Baljit Singh, J. S. Kanwar |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Drug
Polymers and Plastics Biocompatibility media_common.quotation_subject macromolecular substances 02 engineering and technology 010402 general chemistry complex mixtures 01 natural sciences Materials Chemistry Mucoadhesion medicine media_common Psyllium Husk Chemistry technology industry and agriculture 021001 nanoscience & nanotechnology Psyllium 0104 chemical sciences Chemical engineering Drug delivery Self-healing hydrogels Ceramics and Composites Swelling medicine.symptom 0210 nano-technology medicine.drug |
| Zdroj: | Polymer Science, Series B. 60:331-348 |
| ISSN: | 1555-6123 1560-0904 |
| DOI: | 10.1134/s156009041803017x |
| Popis: | In view of the pharmacological importance of dietary fibre, psyllium, to cure the constipation and diverticulitis, in the present study, an attempt has been made to modify psyllium polysaccharide with PVP to develop the hydrogel meant for slow and controlled drug delivery systems. The polymer was characterized by SEMs, FTIR, XRD, TGA and swelling studies. Swelling of hydrogels and drug (ciprofloxacin) release profile from the drug loaded hydrogels were determined for the evaluation of the swelling/release mechanism. Biomedical properties; biocompatibility and mucoadhesion of the hydrogels, were also studied. Swelling of the hydrogels and release of drugs from drug loaded hydrogels occurred through non-Fickian diffusion mechanism. Here it is pertinent to mention that both psyllium husk polysaccharide and antibiotic drug ciprofloxacin are used for gastrointestinal tract (GIT) problem, especially in case of diverticulitis. Hence, degradation of the polymer matrix and release of drug may exert the synergic effect and the present drug delivery system may act with enhanced potential. |
| Databáze: | OpenAIRE |
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