COVID-19 severity associates with pulmonary redistribution of CD1c+ DCs and inflammatory transitional and nonclassical monocytes
| Autor: | Hortensia de la Fuente, Pedro Martínez-Fleta, Ignacio Santos, Ana Alcaraz-Serna, Elena Ávalos, Ana Marcos-Jimenez, Arantzazu Alfranca, Beatriz Aldave, Ana Sanchez-Azofra, Ildefonso Sánchez-Cerrillo, Isidoro González-Álvaro, Luciana del Campo Guerola, Tamara Mateu-Albero, Pedro Landete, Maria J. Calzada, Santiago Sánchez-Alonso, Francisco Sánchez-Madrid, Enrique Martín-Gayo, Ligia Gabrie, Laura Esparcia, Joan B. Soriano, Celia López-Sanz, Cecilia Muñoz-Calleja, Julio Ancochea |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
ARDS Lung Myeloid business.industry T cell Inflammation General Medicine medicine.disease Pathogenesis 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Immune system 030220 oncology & carcinogenesis Immunology medicine medicine.symptom business CD8 |
| Zdroj: | Journal of Clinical Investigation. 130:6290-6300 |
| ISSN: | 1558-8238 0021-9738 |
| Popis: | SARS-CoV-2 is responsible for the development of coronavirus disease 2019 (COVID-19) in infected individuals, who can either exhibit mild symptoms or progress toward a life-threatening acute respiratory distress syndrome (ARDS). Exacerbated inflammation and dysregulated immune responses involving T and myeloid cells occur in COVID-19 patients with severe clinical progression. However, the differential contribution of specific subsets of dendritic cells and monocytes to ARDS is still poorly understood. In addition, the role of CD8+ T cells present in the lung of COVID-19 patients and relevant for viral control has not been characterized. Here, we have studied the frequencies and activation profiles of dendritic cells and monocytes present in the blood and lung of COVID-19 patients with different clinical severity in comparison with healthy individuals. Furthermore, these subpopulations and their association with antiviral effector CD8+ T cell subsets were also characterized in lung infiltrates from critical COVID-19 patients. Our results indicate that inflammatory transitional and nonclassical monocytes and CD1c+ conventional dendritic cells preferentially migrate from blood to lungs in patients with severe COVID-19. Thus, this study increases the knowledge of specific myeloid subsets involved in the pathogenesis of COVID-19 disease and could be useful for the design of therapeutic strategies for fighting SARS-CoV-2 infection. |
| Databáze: | OpenAIRE |
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