Synthesis, Characterization and Crystal Structure of 2-Pyridinecarboxamide
Autor: | Kai-Jin Sun, Zhao-Sheng Cai |
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Rok vydání: | 2019 |
Předmět: | |
Zdroj: | Asian Journal of Chemistry. 32:195-198 |
ISSN: | 0975-427X 0970-7077 |
Popis: | 2-Pyridinecarboxamide was synthesized from 2-picoline through two-steps reaction. Initially, 2-picoline was converted into 2-cyanopyridine by ammoxidation in a stainless-steel fixed-bed reactor at 370 ºC with V2O5 loaded on TiO2 as catalyst. The 2-cyanopyridine was transformed into 2-pyridinecarboxamide through oxidation hydrolysis in basic solution using MnO2 as oxidant at 70 ºC. The final product was characterized by FT-IR, NMR and UV-visible analysis, and 2-pyridinecarboxamide in the final product was determined using HPLC. The crystal structure of 2-pyridinecarboxamide was investigated using X-ray diffraction and SHELX 2018/3 (sh) software and the result indicated that 2-pyridinecarboxamide crystallized in the monoclinic system, space group P21/n with a = 5.207(2), b = 7.097(3), c = 16.243(6) Å, V = 595.7 (4) Å3; Z = 4. |
Databáze: | OpenAIRE |
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