Exercise training rescues impaired H2O2-mediated vasodilation in porcine collateral-dependent coronary arterioles through enhanced K+ channel activation

Autor:	Kalen A. Johnson, Elise Jeffery, Jeff F. Bray, Malea M. Murphy, Cristine L. Heaps
Rok vydání:	2023
Předmět:	Physiology Physiology (medical) Cardiology and Cardiovascular Medicine
Zdroj:	American Journal of Physiology-Heart and Circulatory Physiology. 324:H637-H653
ISSN:	1522-1539 0363-6135
DOI:	10.1152/ajpheart.00710.2022
Popis:	The current study reveals that coronary arterioles distal to stenosis display attenuated dilation responses to H2O2 that are restored with endurance exercise training. Enhanced H2O2 dilation after exercise is dependent on Kv and BKCa channels and at least in part on in colocalization of BKCa channel and PKA and independent of PKA dimerization. These findings expand our earlier studies which demonstrated that exercise training drives beneficial adaptive responses of reactive oxygen species in the microvasculature of the ischemic heart.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::348de2b166663e9331604b33a0b379f7 https://doi.org/10.1152/ajpheart.00710.2022 Zobrazit plný text záznamu