In vitro antioxidant and antidiabetic properties of petroleum ether extract of Wattakaka Volubilis and their potential phytomarkers for insilico computational of biological parameters optimization by using the molecular docking program AutoDock 4
| Autor: | Subhash C. Mandal, Velmani Gopal |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Antioxidant
DPPH medicine.medical_treatment 010401 analytical chemistry 04 agricultural and veterinary sciences AutoDock 040401 food science 01 natural sciences Thin-layer chromatography 0104 chemical sciences Lawsone chemistry.chemical_compound 0404 agricultural biotechnology Complementary and alternative medicine chemistry medicine Organic chemistry Petroleum ether Gallic acid Hydrogen peroxide |
| Zdroj: | Oriental Pharmacy and Experimental Medicine. 16:103-111 |
| ISSN: | 2211-1069 1598-2386 |
| Popis: | Thin layer chromatography was performed to identify the potent phytomarkers such as gallic acid, lawsone and p-coumaric acid in petroleum ether extract of W.volubilis. In vitro antioxidant properties of petroleum ether extract of Wattakaka volubilis (W.volubilis) were evaluated through DPPH, nitric oxide, hydrogen peroxide and hydroxyl radical scavenging. α-amylase and α-glucosidase inhibitory potential of petroleum ether extract of W.volubilis were evaluated through in vitro assay methods, agarose was used as a standard. Insilico computational molecular docking was performed on the phytomarkers with insulin, α-amylase and α-glucosidase pdb proteins by using the program AutoDock 4. |
| Databáze: | OpenAIRE |
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