Correlation between architect hepatitis C virus (HCV) core antigen and HCV Ribonucleic acid levels in Anti-HCV reactive patients in Turkey
| Autor: | Can Gamze, Kaklikkaya Nese, Buruk Kurtulus, Aydin Faruk, Akyuz Zeynep, Koksal Iftihar, Kaya Selcuk, Bayramoglu Gulcin |
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| Rok vydání: | 2013 |
| Předmět: |
biology
business.industry Anti hiv Hepatitis C virus virus diseases RNA Plant Science medicine.disease_cause Microbiology Virology digestive system diseases Hepatitis C virus ribonucleic acid Infectious Diseases Hepatitis C virus RNA Immunology biology.protein Medicine In patient Hcv core antigen Antibody business |
| Zdroj: | African Journal of Microbiology Research. 7:4907-4911 |
| ISSN: | 1996-0808 |
| DOI: | 10.5897/ajmr2012.2300 |
| Popis: | Quantitative tests for the detection of hepatitis C virus ribonucleic acid (HCV-RNA) levels and HCV core antigen have been mainly used for the management of patients with HCV infection. The aim of this study was to evaluate the correlation between HCV core antigen and HCV RNA levels in patients reactive for anti-HCV antibodies. Three hundred and twenty-five anti-HCV reactive sera samples were included in the study. HCV core antigen and HCV RNA levels were determined using the Architect HCV Ag test and Abbott RealTimeTM HCV RNA test (RT-PCR), respectively. The correlation coefficient between the levels of HCV core antigen and HCV RNA test results was calculated using Spearman’s rank test, and linear regression analysis was applied. One hundred and sixteen of the 325 samples were detected positive by both methods. Three additional samples by RT-PCR, and 4 samples by Architect HCV Ag, the negative samples were found positive by the other method. All of these contradictory results were obtained from the low level HCV RNA or HCV core antigen including samples. A correlation coefficient (r) was determined as 0.899 between the levels of HCV core antigen and HCV RNA (p |
| Databáze: | OpenAIRE |
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