ChemInform Abstract: Access to Novel Imidazo[1,5-a]pyrazine Scaffolds by the Combined Use of a Three-Component Reaction and a Base-Assisted Intramolecular Cyclization

Autor:	Gianluca Giorgi, Orazio A. Attanasi, Francesca R. Perrulli, Stefania Santeusanio, Roberta Majer, Gianfranco Favi
Rok vydání:	2014
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Pyrazine Base (chemistry) Chemistry Propargyl Combined use Intramolecular cyclization Regioselectivity Amine gas treating General Medicine Combinatorial chemistry
Zdroj:	ChemInform. 45
ISSN:	0931-7597
DOI:	10.1002/chin.201449175
Popis:	A novel and practical two-step approach to an intriguing class of imidazo[1,5-a]pyrazines with exocyclic CX (X = CH2, O) bonds is described. The process utilizes a sequential three-component reaction of propargyl amine or aminoester, 1,2-diaza-1,3-dienes and isothiocyanates to furnish functionalized 2-thiohydantoins which are transformed into thiohydantoin-fused tetrahydropyrazines by subsequent regioselective base-promoted cyclization.
Databáze:	OpenAIRE
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