ChemInform Abstract: Synthesis of Mono N-Substituted Guanylthioureas

Autor:	Rhonda A. Bryant, Lawrence A. Reiter, Katherine E. Brighty, Goldsmith Miriam E
Rok vydání:	2010
Předmět:	Substitution reaction chemistry.chemical_compound Chemistry Hydrogen sulfide Dithiobiuret Single step General Medicine Combinatorial chemistry Derivative (chemistry)
Zdroj:	ChemInform. 27
ISSN:	0931-7597
DOI:	10.1002/chin.199632049
Popis:	A convenient method for the synthesis of mono N-substituted guanylthioureas in reasonable yields from readily available starting materials has been developed. In contrast to the previously published method, the use of highly noxious hydrogen sulfide is avoided. The method allows the rapid preparation of guanylthioureas since the synthesis of each requires only a single step from a common intermediate, the S-methylated derivative of dithiobiuret.
Databáze:	OpenAIRE
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