Synthesis of 3,4-dihydrothioxanthene-1,9-dione analogs as potential antimalarial agents

Autor:	Dennis Joseph Mcnamara, Leslie M. Werbel, Hung Jocelyn H
Rok vydání:	1983
Předmět:	chemistry.chemical_compound chemistry biology Stereochemistry Organic Chemistry Acetal FLOXACRINE Sulfoxide Plasmodium berghei Antimalarial Agent biology.organism_classification Combinatorial chemistry Sulfone
Zdroj:	Journal of Heterocyclic Chemistry. 20:1575-1580
ISSN:	1943-5193 0022-152X
Popis:	7-Chloro-3-(2,4-dichlorophenyl)-3,4-dihydro-1H-thioxanthene-1,9 (2H)-dione (10), and a variety of analogs and derivatives were prepared as sulfur isosteric analogs of the acridinedione antimalarial agent, floxacrine. The compounds were devoid of antimalarial activity against P. berghei in mice.
Databáze:	OpenAIRE
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