Prognostic value of soluble interleukin 2 receptor levels in Langerhans cell histiocytosis

Autor:	Marta Zelazko, Jorge Braier, Diego Rosso, Adriana Roy
Rok vydání:	2002
Předmět:	Interleukin 2 Pathology medicine.medical_specialty business.industry medicine.medical_treatment Organ dysfunction Hematology medicine.disease Histiocytosis Cytokine Langerhans cell histiocytosis Predictive value of tests medicine medicine.symptom business Survival rate Histiocyte medicine.drug
Zdroj:	British Journal of Haematology. 117:54-58
ISSN:	0007-1048
DOI:	10.1046/j.1365-2141.2002.03400.x
Popis:	We investigated the prognostic significance of soluble interleukin 2 receptor (sIL-2r) levels in the pre- and post-treatment serum of paediatric patients with Langerhans cell histiocytosis (LCH). Serum levels of sIL-2r from 32 LCH patients and 14 healthy controls were determined using enzyme-linked immunosorbent assay. The LCH patients were classified, evaluated and treated according to the Histiocyte Society's protocols. The following clinical stages were considered: single-system disease (A) divided into single-site (A1; n=4), multiple-site (A2; n=9), and multisystem disease (B) without organ dysfunction (B1; n=5) and with organ dysfunction (B2; n=14). Pretreatment concentrations of sIL-2r were markedly increased at diagnosis in LCH patients compared with controls [in pg/ml, median (range) 9200 (1124-40000) versus 610 (343-800)], P or = 17500 pg/ml of sIL-2r had a 30-month survival of 0.417 (SEM: 0.142) compared with those with levels or = 17500 pg/ml were found to have greater predictive strength than other well-known prognostic factors.
Databáze:	OpenAIRE
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