In-silico validation of Apocynin and NADPH Oxidase (NOX) enzyme for inhibiting ROS injuries
| Autor: | Divya Jindal, Vinayak Agarwal, Shriya Agarwal, Ashok Kumar Tiwari, Manisha Singh, Vandana Tyagi, R Rachana, Vaibhav Gandhi |
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| Rok vydání: | 2023 |
| Předmět: |
inorganic chemicals
chemistry.chemical_classification NADPH oxidase biology In silico Protein subunit Molecular Docking Analysis Active site General Medicine respiratory system chemistry.chemical_compound Enzyme chemistry Biochemistry Apocynin cardiovascular system biology.protein NOx circulatory and respiratory physiology |
| Zdroj: | Materials Today: Proceedings. 80:2375-2377 |
| ISSN: | 2214-7853 |
| Popis: | The present study was focused to analyse and evaluate potential targets of NADPH Oxidase (NOX) at varying sub-units and co-relating their interactions with apocynin to identify appropreiate mechanism of inhibition for NOX by applying specific facets of computational biology . Active site molecular docking analysis was carried for apocynin against various subunits of NOX and comparatively analysise the binding affinity profiles which were obtained when apocynin was docked with p47phox complete subunit of NOX and all the other subunits. |
| Databáze: | OpenAIRE |
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