A platform direct compression formulation for low dose sustained-release tablets enabled by a dual particle engineering approach
| Autor: | Changquan Calvin Sun, Aktham Aburub, Hongbo Chen, Wei Jhe Sun |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Materials science
General Chemical Engineering Low dose Composite number Drug release rate 02 engineering and technology 021001 nanoscience & nanotechnology Compression (physics) Design for manufacturability Tableting 020401 chemical engineering Particle 0204 chemical engineering 0210 nano-technology Biomedical engineering |
| Zdroj: | Powder Technology. 342:856-863 |
| ISSN: | 0032-5910 |
| DOI: | 10.1016/j.powtec.2018.10.054 |
| Popis: | Content uniformity (CU) is a well-recognized challenge for low-dose direct compression (DC) tablet formulations. Using a dual particle engineering approach that involves a) forming a segregation-resistant drug-carrier composite to improve CU and b) nanocoating HPMC to enhance flowability, we have developed a platform DC formulation for preparing low-dose drug sustained-release (SR) tablets with excellent CU. In addition to demonstrated robustness in manufacturability, this platform formulation has the flexibility for modifying drug release rate. Thus, it is useful for expedited and material-sparing development of low dose SR tablets using the economical DC process. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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