Practical synthesis of Vistusertib (AZD2014), an ATP competitive mTOR inhibitor

Autor:	Miaoqing Liu, Jianjun Lu, Guobing Shen, Tao Meng
Rok vydání:	2019
Předmět:	010405 organic chemistry Chemistry Kinase Organic Chemistry VISTUSERTIB Biological activity 010402 general chemistry Discovery and development of mTOR inhibitors 01 natural sciences Biochemistry 0104 chemical sciences Atp competitive Yield (chemistry) Drug Discovery PI3K/AKT/mTOR pathway
Zdroj:	Tetrahedron Letters. 60:151333
ISSN:	0040-4039
Popis:	Vistusertib (AZD2014) is a potent, selective inhibitor of mTOR kinase. Prompted by its fascinating biological activity, an efficient and practical synthesis of Vistusertib has been developed from 3-acetylbenzoic acid through six steps in 48% overall yield.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3479c58ea89ce437f77f8d087ac3909b https://doi.org/10.1016/j.tetlet.2019.151333 Zobrazit plný text záznamu Full Text from ScienceDirect