Porous Polylactic Acid-Silica Hybrids: Preparation, Characterization, and Study of Mesenchymal Stem Cell Osteogenic Differentiation
| Autor: | Joana Matos, Apostolos Kyritsis, S. Madeira, João F. Mano, Joaquín Ródenas-Rochina, S. Kripotou, Christos Pandis, Sara Trujillo, José Luis Gómez Ribelles |
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| Rok vydání: | 2014 |
| Předmět: |
chemistry.chemical_classification
Polymers and Plastics Mesenchymal stem cell Bioengineering 02 engineering and technology Polymer 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Biomaterials Extracellular matrix chemistry.chemical_compound Membrane chemistry Chemical engineering Polylactic acid Phase (matter) Materials Chemistry Composite material 0210 nano-technology Hybrid material Porosity Biotechnology |
| Zdroj: | Macromolecular Bioscience. 15:262-274 |
| ISSN: | 1616-5187 |
| DOI: | 10.1002/mabi.201400339 |
| Popis: | A novel approach to reinforce polymer porous membranes is presented. In the prepared hybrid materials, the inorganic phase of silica is synthesized in-situ and inside the pores of aminolyzed polylactic acid (PLA) membranes by sol-gel reactions using tetraethylorthosilicate (TEOS) and glycidoxypropyltrimethoxysilane (GPTMS) as precursors. The hybrid materials present a porous structure with a silica layer covering the walls of the pores while GPTMS serves also as coupling agent between the organic and inorganic phase. The adjustment of silica precursors ratio allows the modulation of the thermomechanical properties. Culture of mesenchymal stem cells on these supports in osteogenic medium shows the expression of characteristic osteoblastic markers and the mineralization of the extracellular matrix. |
| Databáze: | OpenAIRE |
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