An Alternative Way to Prepare Biocompatible Nanotags with Increased Reproducibility of Results
| Autor: | Markus Haase, Mohammad Salehi, Wilrun Mittelstädt, Jens Packeisen, Angela Hamann-Steinmeier |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
Reproducibility Biomolecule food and beverages Nanoparticle Nanotechnology 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Biocompatible material 01 natural sciences 0104 chemical sciences chemistry 0210 nano-technology Biomedical engineering |
| Zdroj: | Journal of Nanomaterials & Molecular Nanotechnology. |
| ISSN: | 2324-8777 |
| DOI: | 10.4172/2324-8777.1000181 |
| Popis: | An Alternative Way to Prepare Biocompatible Nanotags with Increased Reproducibility of Results Aggregation of nanoparticles (NP) occurs mostly during and after their biofunctionalization. Aggregations can lead to disfunction of the biomolecule which binds to NP like antibodies or enzymes. In many cases, disfunctions and the lack of reproducibility of the results are two major challenges during the use of nanotechnology. We demonstrate that the aggregation of nanoparticles can be controlled by choosing the optimal amount of crosslinker and furthermore the function of biomolecules can be protected by avoiding centrifugation steps. These investigations may provide a valuable guide in many other medical applications of nanostructures. |
| Databáze: | OpenAIRE |
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