Antifouling fluoropolymer-coated nanomaterials for 19F MRI
| Autor: | Daniel Jirak, Ognen Pop-Georgievski, Jan Svoboda, Ondrej Sedlacek, Marcela Filipová |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Materials science Metals and Alloys Nanoparticle Nanotechnology General Chemistry Polymer Polyethylene glycol engineering.material Catalysis Surfaces Coatings and Films Electronic Optical and Magnetic Materials Nanomaterials Biofouling chemistry.chemical_compound chemistry Coating Electromagnetic shielding Materials Chemistry Ceramics and Composites engineering Fluoropolymer |
| Zdroj: | Chemical Communications. 57:4718-4721 |
| ISSN: | 1364-548X 1359-7345 |
| Popis: | We developed a multifunctional polymer coating for nanoparticles (NPs) that enables simultaneous detection by 19F MRI and shielding from blood plasma fouling. The coating is based on a water-soluble fluorinated poly(N-(2-fluoroethyl)acrylamide) (PFEAM) that shows high 19F MRI sensitivity, cytocompatibility and excellent antifouling properties, significantly outperforming polyethylene glycol. A proof-of-concept experiment was performed by synthesizing polymer-coated gold NPs that were successfully visualized by 19F MRI at magnetic fields close to the fields used in clinical practice. This universal approach can be used for coating and tracing of various NPs upon suitable polymer chain-end modification. |
| Databáze: | OpenAIRE |
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