Histopathological effects with marwar teak (tecomella undulata) bark extract and N-acetylcysteine on acetaminophen induced hepatotoxicity in albino rats
| Autor: | null Mehr Fatima, null Muhammad Kamran, null Shabih Zehra, null Nighat Jamil, null Ijaz Hussain Zaidi |
|---|---|
| Rok vydání: | 2022 |
| Zdroj: | The Professional Medical Journal. 29:345-350 |
| ISSN: | 2071-7733 1024-8919 |
| DOI: | 10.29309/tpmj/2022.29.03.6669 |
| Popis: | Objective: The study aims to determine histopathological effects associated with Marwar Teak Tecomella Undulata bark extract and N-Acetylcysteine on Acetaminophen induced liver damage in rats. Study Design: Experimental Comparative Study. Setting: Bahria University Medical and Dental College Karachi in Collaboration with Basic Medical Sciences Institute (BMSI) Karachi. Period: March 2020 till August 2020. Material & Methods: Study included 56 healthy albino rats which were randomly divided into four groups. Each group comprised of 14 experimental animals which included (Group-1) Control Group, (Group-2) hepatotoxicity induced rats, which were given Acetaminophen 500 mg as a single dose orally, (Group 3) which was induced hepatotoxicity by Acetaminophen 500mg orally as a single dose, then they were given N-Acetylcysteine standard drug at dosage of 140mg/ kg intraperitonealy for 6 days and (Group 4), which was induced hepatotoxicity by Acetaminophen 500 mg orally as a single dose, then they were given Tecomella bark extract at the dose of 200 mg/kg orally for 15 days. Experimental animals were dissected. Liver samples were sectioned (3-5µ) thickness and were stained with H&E. Histopathological findings were noted. SPSS version 23 was used for statistical analysis. P-value |
| Databáze: | OpenAIRE |
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