Calcific aortic stenosis: Study of serum cholesterol
| Autor: | Ernst P. Boas, Samuel K. Elster, David Adlersberg |
|---|---|
| Rok vydání: | 1954 |
| Předmět: |
Aortic valve
medicine.medical_specialty education.field_of_study business.industry Population Rheumatic valvular disease medicine.disease Surgery Stenosis medicine.anatomical_structure Internal medicine Aortic valve stenosis cardiovascular system Cardiology medicine Rheumatic fever Cardiology and Cardiovascular Medicine Familial hypercholesteremia education business Serum cholesterol |
| Zdroj: | American Heart Journal. 48:485-496 |
| ISSN: | 0002-8703 |
| DOI: | 10.1016/0002-8703(54)90115-5 |
| Popis: | The serum cholesterol of eighty-six patients with aortic stenosis, forty-three men and forty-three women, and of sixty-seven patients with chronic rheumatic valvular disease, twenty-two men and forty-five women, was determined. Using Keys' standards, 48.8 per cent of the females and 18.6 per cent of the males with aortic stenosis were hypercholesteremic, whereas of those with chronic rheumatic valvular disease 13.3 per cent of the females and 13.6 per cent of the males were hypercholesteremic. By using standards derived from a study of a random sample of a union population in New York City (The Amalgamated Clothing Workers of America), 53.5 per cent of the females and 27.9 per cent of the males with aortic stenosis were hypercholesteremic; and of those with rheumatic valvular disease 20 per cent of the women and 18.2 per cent of the men were hypercholesteremic. Of the patients with aortic stenosis 70 per cent apparently had had previous rheumatic infection. Three patients with xanthomatosis and hypercholesteremia and one with familial hypercholesteremia who also had aortic stenosis were observed. Only one of these had had rheumatic fever. One was a man aged 20. Our material favors the hypothesis that in persons with hypercholesteremia aortic stenosis may be caused by atherosclerosis of a normal aortic valve, but that in most instances it is caused by a secondary atherosclerosis implanted on aortic cusps scarred by ancient rheumatic infection. |
| Databáze: | OpenAIRE |
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